نیکوتینیک اسید دوخفا(NICOTINIC ACID duchefa) , نیکوتینیک اسید دوخفا










plant tissue culture media and biochemicals


Nicotinic Acid

Safety Data Sheet                                                                                                                           N0611


according to Regulation (EU) 2015/830

Date of issue: 14/09/2010       Revision date: 07/11/2017 Supersedes 06/01/2012


Version: 2.0



SECTION 1: Identification of the substance/mixture and of the company/undertaking

    1. Product identifier

Product form                                        : Substance

Trade name                                          : Nicotinic Acid

EC-No.                                                 : 200-441-0

CAS-No.                                              : 59-67-6

REACH registration No                         : 01-2119968267-24

Product code                                       : N0611

Formula                                               : C6H5NO2

Product group                                      : Raw material


    1. Relevant identified uses of the substance or mixture and uses advised against
      1. Relevant identified uses

Main use category                                : Professional use

Industrial/Professional use spec            : For professional use only. Duchefa Biochemie B.V. products are intended

only for "in vitro laboratory" research purposes.


      1. Uses advised against

No additional information available

    1. Details of the supplier of the safety data sheet Supplier

Duchefa Biochemie B.V.

A. Hofmanweg 71

2031 BH Haarlem - The Netherlands

T +31(0)23-5319093 - F +31(0)23-5318027


    1. Emergency telephone number

Emergency number                                                      : Supplier contact information:

+31(0)23-5319093 (M-F 09:00-17:00)

+31(0)6-30109355 (outside office hours)





World Health Organization world directory of poison centres

Consult website for a local poison centre


SECTION 2: Hazards identification                                                                                    

    1. Classification of the substance or mixture

Classification according to Regulation (EC) No. 1272/2008 [CLP]

Serious eye damage/eye irritation, Category 2                                         H319 Full text of hazard classes and H-statements : see section 16

Adverse physicochemical, human health and environmental effects

No additional information available




    1. Label elements

Labelling according to Regulation (EC) No. 1272/2008 [CLP]


Hazard pictograms (CLP)                      :





Signal word (CLP)                                 : Warning

Hazard statements (CLP)                       : H319 - Causes serious eye irritation. Precautionary statements (CLP)             : P262 - Do not get in eyes, on skin, or on clothing.

P280 - Wear eye protection, face protection, protective clothing, protective gloves.

P305+P351 - IF IN EYES: Rinse cautiously with water for several minutes.


    1. Other hazards

No additional information available


SECTION 3: Composition/information on ingredients                                                       

    1. Substances

Name                                                   : Nicotinic Acid

CAS-No.                                              : 59-67-6

EC-No.                                                 : 200-441-0



Product identifier


Nicotinic acid

(CAS-No.) 59-67-6

(EC-No.) 200-441-0

> 99


Full text of H-statements: see section 16


    1. Mixtures

Not applicable


SECTION 4: First aid measures                                                                                         

    1. Description of first aid measures


First-aid measures after inhalation          : Assure fresh air breathing.

First-aid measures after skin contact     : Seek medical attention if ill effect or irritation develops. Wash skin with

plenty of water and soap.

First-aid measures after eye contact      : Rinse immediately with plenty of water. Obtain medical attention if pain,

blinking or redness persist.

First-aid measures after ingestion          : Rinse mouth. Seek medical attention if ill effect develops.


    1. Most important symptoms and effects, both acute and delayed

Symptoms/effects                                : Affects the nervous system. Vomiting. Nausea. Unconsciousness. Reduced

blood pressure.


    1. Indication of any immediate medical attention and special treatment needed

No additional information available



SECTION 5: Firefighting measures                                                                                    

    1. Extinguishing media

Suitable extinguishing media                 : Alcohol resistant foam. Dry chemical powder. Carbon dioxide (CO2). Water



    1. Special hazards arising from the substance or mixture


Hazardous decomposition products in case of fire

    1. Advice for firefighters


: When exposed to heat, may decompose liberating hazardous gases. COx. NOx.


Precautionary measures fire                  : Do not enter fire area without proper protective equipment, including

respiratory protection.

Firefighting instructions                        : Use water spray or fog for cooling exposed containers.

SECTION 6: Accidental release measures                                                                          

    1. Personal precautions, protective equipment and emergency procedures

General measures                                 : Avoid raising powdered materials into airborne dust.


      1. For non-emergency personnel

Protective equipment                            : Equip cleanup crew with proper protection.

      1. For emergency responders

No additional information available


    1. Environmental precautions

Prevent entry to sewers and public waters.


    1. Methods and material for containment and cleaning up

Methods for cleaning up                       : Sweep up dry powder and dispose properly.

    1. Reference to other sections

No additional information available


SECTION 7: Handling and storage                                                                                     

    1. Precautions for safe handling

Precautions for safe handling                : Handle in accordance with good industrial hygiene and safety procedures.


    1. Conditions for safe storage, including any incompatibilities

Storage conditions                               : Store in dry, well-ventilated area. Store at ambient temperature. Keep

container closed when not in use.


    1. Specific end use(s)

For professional use only. Duchefa Biochemie B.V. products are intended only for "in vitro laboratory" research purposes.


SECTION 8: Exposure controls/personal protection                                                          

    1. Control parameters


Nicotinic Acid (59-67-6)

DNEL/DMEL (Workers)

Long-term - systemic effects, dermal

0,14 mg/kg bodyweight/day

Long-term - systemic effects, inhalation

0,5 mg/m³



Nicotinic Acid (59-67-6)

DNEL/DMEL (General population)

Long-term - systemic effects,oral

0,14 mg/kg bodyweight/day

Long-term - systemic effects, inhalation

0,25 mg/m³

Long-term - systemic effects, dermal

0,14 mg/kg bodyweight/day

PNEC (Water)

PNEC aqua (freshwater)

0,077 mg/l

PNEC aqua (marine water)

0,0077 mg/l

PNEC (Sediment)

PNEC sediment (freshwater)

0,1221 mg/kg dwt

PNEC sediment (marine water)

0,0122 mg/kg dwt

PNEC (Soil)

PNEC soil

0,043 mg/kg dwt


PNEC sewage treatment plant

8,8 mg/l




Thickness (mm)



Nitrile rubber (NBR)

6 (> 480 minutes)


EN 374



Exposure controls Hand protection:




Eye protection:

Safety glasses (to European standard EN 166 or equivalent)

Skin and body protection:

Long sleeved protective clothing

Respiratory protection:

Wear appropriate mask. Filter type P3 (EN 143)


SECTION 9: Physical and chemical properties                                                                  

    1. Information on basic physical and chemical properties

Physical state                                       : Solid

Appearance                                          : Powder. Crystalline powder.

Molecular mass                                    : 123,11 g/mol

Colour                                                  : White.

Odour                                                  : Odourless.

Odour threshold                                   :  No data available

pH                                                       :  2,7 (18 g/l, 20 °C)


Relative evaporation rate (butylacetate=1)


: No data available


Melting point                                        : 236,6 °C

Freezing point                                      :  No data available

Boiling point                                         :  No data available

Flash point                                           : 193 °C

Auto-ignition temperature                      : > 365 °C

Decomposition temperature                  :  No data available

Flammability (solid, gas)                       :  No data available

Vapour pressure                                   : No data available Relative vapour density at 20 °C            : 4,25

Relative density                                    : No data available



Density                                                : 1,479 g/cm³ (20 °C)

Solubility                                              : Water: 18 g/l (20 °C)


Log Pow                                              : -2,43 (25 °C, OECD Test 107)

Viscosity, kinematic                              :  No data available

Viscosity, dynamic                               :  No data available

Explosive properties                             :  No data available

Oxidising properties                             :  No data available

Explosive limits                                    :  No data available


    1. Other information

Bulk density                                         : ≈ 330 kg/m³


SECTION 10: Stability and reactivity                                                                                  

    1. Reactivity

No additional information available

    1. Chemical stability

Stable under normal conditions of storage, handling and use.

    1. Possibility of hazardous reactions

No additional information available

    1. Conditions to avoid


    1. Incompatible materials

Oxidising agents. Acids. Bases.

    1. Hazardous decomposition products

According to process conditions, hazardous decomposition products may be generated. COx. NOx.


SECTION 11: Toxicological information                                                                            

11.1.     Information on toxicological effects

Acute toxicity                                       :  Not classified


Nicotinic Acid (59-67-6)

LD50 oral rat

7000 mg/kg

LD50 dermal rat

> 2000 mg/kg

Skin corrosion/irritation                         :  Not classified

pH: 2,7 (18 g/l, 20 °C)

Serious eye damage/irritation                : Causes serious eye irritation.

pH: 2,7 (18 g/l, 20 °C)

Respiratory or skin sensitisation            : Not classified Germ cell mutagenicity          :  Not classified

Carcinogenicity                                    :  Not classified


Reproductive toxicity                            :  Not classified

STOT-single exposure                          :  Not classified

STOT-repeated exposure                      :  Not classified




Nicotinic Acid (59-67-6)

NOAEL (subacute, oral, animal/male, 28 days)

50 mg/kg bodyweight

NOAEL (subacute, oral, animal/female, 28 days)

50 mg/kg bodyweight

Aspiration hazard                                  : Not classified

Other information                                  : See actual entry in RTECS for complete information: QT0525000.

SECTION 12: Ecological information                                                                                 

    1. Toxicity


Nicotinic Acid (59-67-6)

LC50 fish 1

520 mg/l (96 h, Oncorhynchus mykiss (Rainbow trout))

EC50 Daphnia 1

77 g/l (Daphnia magna, 48 h)


    1. Persistence and degradability


Nicotinic Acid (59-67-6)

Persistence and degradability

Product is biodegradable.

BOD (% of ThOD)

100 % ThOD


100 %


    1. Bioaccumulative potential


Nicotinic Acid (59-67-6)

Log Pow

-2,43 (25 °C, OECD Test 107)

Bioaccumulative potential

No bioaccumulation.


    1. Mobility in soil

No additional information available


    1. results of PBT and vPvB assessment

No additional information available


    1. Other adverse effects

Additional information                           : Prevent entry to sewers and public waters

SECTION 13: Disposal considerations                                                                               

13.1.     Waste treatment methods

Waste treatment methods                     : Dispose in a safe manner in accordance with local/national regulations.

SECTION 14: Transport information                                                                                  

In accordance with ADR / IATA / IMDG





14.1.     UN number

Not regulated

Not regulated

Not regulated

14.2.     UN proper shipping name

Not regulated

Not regulated

Not regulated

Not regulated

Not regulated

Not regulated






14.3.     Transport hazard class(es)

Not regulated

Not regulated

Not regulated

Not regulated

Not regulated

Not regulated

14.4.     Packing group

Not regulated

Not regulated

Not regulated

14.5.     Environmental hazards

Not regulated

Not regulated

Not regulated

No supplementary information available

    1. Special precautions for user
  • Overland transport

Not regulated

  • Transport by sea

Not regulated

  • Air transport

Not regulated

    1. Transport in bulk according to Annex II of Marpol and the IBC Code

Not applicable


SECTION 15: Regulatory information                                                                                


    1. Safety, health and environmental regulations/legislation specific for the substance or mixture
      1. EU-Regulations

No REACH Annex XVII restrictions

Nicotinic Acid is not on the REACH Candidate List Nicotinic Acid is not on the REACH Annex XIV List


      1. National regulations

Ensure all national/local regulations are observed.



VwVwS Annex reference                       : Water hazard class (WGK) 1, low hazard to waters (Classification according

to VwVwS, Annex 1 or 2; ID No. 1368)


12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV


SZW-lijst van kankerverwekkende stoffen


: Is not subject of the 12. BlmSchV (Hazardous Incident Ordinance)




: The substance is not listed


SZW-lijst van mutagene stoffen             : The substance is not listed


NIET-limitatieve lijst van voor de voortplanting giftige stoffen – Borstvoeding

NIET-limitatieve lijst van voor de voortplanting giftige stoffen – Vruchtbaarheid


:  The substance is not listed



:  The substance is not listed




NIET-limitatieve lijst van voor de voortplanting giftige stoffen – Ontwikkeling


: The substance is not listed



    1. Chemical safety assessment

No additional information available


SECTION 16: Other information                                                                                         

Indication of changes:


Emergency number




Suitable extinguishing media


Alcohol resistant foam


Control parameters




Hand protection


Specified material, thickness, et cetera of gloves


Flash point




Auto-ignition temperature








Abbreviations and acronyms:


Acute Toxicity Estimate


European Agreement concerning the International Carriage of Dangerous Goods by Road


Bioconcentration factor


Classification Labelling Packaging Regulation; Regulation (EC) No 1272/2008


Dangerous Preparations Directive 1999/45/EC


Dangerous Substances Directive 67/548/EEC


International Air Transport Association


International Maritime Dangerous Goods


Median lethal concentration


Median lethal dose


Lowest Observed Adverse Effect Level


No-Observed Adverse Effect Concentration


Persistent Bioaccumulative Toxic


Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation (EC) No 1907/2006


Safety Data Sheet

Data sources                                        : ECHA (European Chemicals Agency). Supplier.


Full text of H- and EUH-statements:

Eye Irrit. 2

Serious eye damage/eye irritation, Category 2


Causes serious eye irritation.


SDS Biochemicals version 2017


This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product

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